Vascular hemophilic factor (vWF) is a multimeric glycoprotein present in plasma that produces oversized vWF in the endothelium (Weibel-Palade vesicles), megakaryocytes (platelet alpha-granules), and subendothelial connective tissues. vWF multimers have a very high molecular weight (greater than 20,000 kDa) and consist of more than 80 subunits with a molecular weight of 250 kDa. The main function of vWF is to bind other proteins, especially factor VIII, which plays an important role in platelet adhesion to the wound site, and additionally, it plays an important role in the coagulation process. Therefore, vWF deficiency or dysfunction (vascular hemophilia) will result in a tendency to bleed, most notably in tissues with high blood flow in narrow vessels. Monitoring serum levels of vWF may provide more detailed insight into pathologies such as thrombotic thrombocytopenic purpura, Hyde’s syndrome, and possibly hemolytic uremic syndrome.