Vascular endothelial growth factor C (VEGF-C) is a dimeric secreted protein, a member of the PDGF/VEGF family. Translated VEGF-C has three structural domains: the middle VEGF homology domain (VHD), the N-terminal structural domain (prepeptide), and the C-terminal structural domain (pre-peptide).VEGF-C has an important role in lymphangiogenesis and acts on lymphatic vessel endothelial cells mainly by binding to its receptor, VEGFR-3, thereby promoting their survival, growth, and migration. Studies have demonstrated that VEGF-C is a specific growth factor for lymphatic vessels in a variety of models.In addition to its effects on lymphatic vessels, VEGF-C promotes vascular growth and regulates vascular permeability by binding to its primary receptor, VEGFR-3, or secondary receptor, VEGFR-2. In addition, VEGF-C is important for neural development and blood pressure regulation. Deficiency of VEGF-C leads to lymphedema, while excess VEGF-C is associated with tumor angiogenesis and metastasis.