Leukocyte antigen differentiation Cluster 30(CD30), also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8), is a membrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated rather than resting T and B cells. CD30 may play a role in the regulation of cell growth and activated lymphoblastic transformation, and may also play an important role in human immunodeficiency virus replication. TRAF2 and TRAF5 can interact with this receptor and mediate the formation of NF-κ B activated signal transduction. As a positive regulator of apoptosis, CD30 protein can induce cell death or proliferation depending on cell type and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in a variety of hematological malignancies, and CD30 is also associated with white blood cells in patients with chronic inflammatory diseases, such as lupus erythematosus, asthma, and rheumatoid arthritis.