E-selectin, also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1) or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a 115 kDa glycoprotein that is expressed only after activation by inflammatory cytokines (IL-1β or TNF-α) or endotoxin in endothelial cells. Cell surface E-selectin mediates leukocyte attachment to the endothelium and thus plays an important role in the local inflammatory response.The extracellular region of E-selectin consists of a calcium-dependent C2-type lectin structural domain, an epidermal growth factor (EGF) structural domain, and six repetitive complement regulatory protein-like sequences. Soluble E-selectin (sE-Selectin) is present in the blood of healthy organisms and may arise from protein cleavage of surface-expressed molecules. Monitoring serum levels of sE-Selectin may provide more detailed insights into a number of pathologic conditions such as cancer, infectious diseases, diabetes, and sepsis.