The Notch signaling pathway is a ubiquitous pathway that controls developmental processes. The Notch family consists of a group of highly conserved proteins that are both cell surface receptors and direct regulators of gene transcription. It plays an important regulatory role in cell proliferation, apoptosis, differentiation and a series of physiological and pathological processes, and plays a crucial role in the occurrence and development of cancer. Notch-1, a 300kDa type 1 transmembrane glycoprotein, is one of the four Notch homologues involved in developmental processes. Members of this type 1 transmembrane protein family share the same structural characteristics, including an extracellular domain composed of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of multiple different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. Notch-1 pathway is associated with cell differentiation, proliferation, apoptosis and adhesion. Abnormal activation of Notch-1 signaling pathway has been linked to the development of cancer.