Lymphatic endothelial hyaluronan receptor-1 (LYVE-1), as a lymphatic endothelial-specific marker, is specifically expressed in lymphatic endothelial cells and is uniformly distributed in the basal and luminal surfaces of lymphatic endothelial cells, and its wide application promotes research in the field of tumor lymphatic metastasis. In recent years, the biological function of LYVE-1 itself and the role it plays in the field of tumor metastasis have become one of the hotspots of tumor metastasis research. Elucidating the mechanism of LYVE-1’s role in tumor lymphatic metastasis is of great significance for the establishment of new methods of tumor therapy.