Vascular endothelial growth factor receptor 3 (VEGF R3), also known as Flt-4, is a tyrosine kinase receptor for VEGF-C and VEGF-D. This protein is involved in the generation and maintenance of lymphatic vessels in the lymphatic endothelium. High expression of VEGF R3 can be found in lymphatic endothelial cells isolated from cancer tissue of lymphoma patients. Mutations in the VEGF R3 gene lead to IA type hereditary lymphedema. Some studies have shown a positive correlation between the expression of VEGF-C, VEGF-D, and VEGFR3 and the involvement of vascular invasion, lymphatic vessels, and lymph nodes. VEGF-C/VEGF-D/VEGFR3 signaling pathway can provide targets for anti lymphangiogenesis therapy of prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer, etc.