Epidermal growth factor receptor (EGFR), also known as ErbB1 and HER1, is a type I transmembrane glycoprotein. It exists on the surface of cells and relies on its specific ligands, including EGF and TGF- α Combine to activate. EGFR signaling plays an important role in regulating cell proliferation, survival, and differentiation. After binding with ligands, EGFR induces homologous or heterodimerization, leading to subsequent tyrosine self phosphorylation and various downstream pathways (MAPK, PI3K/PKB, and STAT). The activation of this receptor plays an important role in the innate immune response of human skin, and overexpression (upregulation) or excessive activity of EGFR is associated with many cancers, including lung cancer, anal cancer, and glioblastoma multiforme. Abnormal EGFR signal is related to psoriasis, eczema and atherosclerosis. At present, researchers believe that EGFR can be a target for cancer treatment.