Chemokine C-C motif ligand 25 (CCL25), also known as thymus-expressed chemokine (TECK), is a chemokine produced by stromal cells of the thymus and by epithelial cells of the small intestine, particularly the jejunum and ileum.CCL25 induces the homing of several populations of lymphocytes to the small intestine, including the integrin a4b7 + & gamma;/δ T-cells, integrin aEb7 + CD8 + T cells, and IgA-producing plasma cells.CCL25 acts upon binding the chemokine receptor CCR9.CCL25 attracts CCR9 + monocytes and macrophages in rheumatoid arthritis and CCR9 + macrophages in atherosclerosis. In addition, CCL25 appears to be a new promising candidate for recruiting MSCs and therefore promoting in situ regeneration. In cancer, CCL25 promotes metastasis of melanoma cells to the small intestine, migration and invasion of certain breast cancers and attraction of MSC to multiple myeloma.