Angiotensin-converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and zinc metalloproteinase of the ACE family.ACE2 is a key enzyme in the renin-angiotensin system for the regulation of blood pressure.ACE-2 cleaves angiotensin I and II as carboxypeptidases. Specifically, ACE2 cleaves the terminal natriuretic peptide from angiotensin I or the terminal heptapeptide from angiotensin II to produce angiotensin, respectively. The resulting peptides resist the action of angiotensin II and act as vasodilators.ACE-2 has been shown to be a functional receptor for the human coronaviruses SARS-CoV and SARS-CoV-2.