Product Category
Newest Products
Human IL-17A High Sensitivity ELISA Kit
$380.00 – $480.00
| Sample Type | Serum, plasma, cell culture supernatant, and other biological samples |
|---|---|
| Sample Volume | Serum, plasma: 20 μL；cell culture supernatant: 100 μL |
| Sensitivity | 0.20 pg/mL |
| Range | 0.78 pg/mL – 50 pg/mL |
| Assay Time | 3.5 h |
| Recovery | 80% – 95% |
| Average Recovery | 0.86 |
| Intra Precision | 4.3% – 4.6% |
| Inter-Precision | 5.9% – 9.0% |
| Platform | ELISA |
| Plate | Detachable 96-well plate |
| Size | 96T/48T |
| Storage | If the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃. |
| Delivery | 4℃ blue ice transportation |
| Components | 96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-IL-17A monoclonal antibody Human IL-17A freeze-dried standard IL-17A detect Antibody Standard Diluent HRP-labeled streptavidin Signal enhancer concentrate Signal enhancer diluent Assay Buffer(10×) Substrate TMB Stop Solution Washing Buffer(20×) |
| Assay Principle | This kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-human IL-17A antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and biotinylated detection antibodies are added to the wells of the ELISA plate. After incubation, IL-17A present in the samples binds to the solid-phase antibodies and the detection antibodies. After washing to remove unbound substances, streptavidin-HRP labeled with horseradish peroxidase is added. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of IL-17A in the samples.A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm). |
Targets
IL17A
IL17A Target Infomation Overview
- Target Symbol: IL17A, interleukin 17A
- Gene Groups: Interleukins
- Alias: IL-17A; IL-17
- Previous Names: CTLA8; IL17
- Alias Names: cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
IL17A, interleukin 17A Target Infomation by Species
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Human IL17A Target Information
- Target Symbol: IL17A, interleukin 17A
- Alias:
- CTLA-8
- CTLA8
- cytotoxic T-lymphocyte-associated antigen 8
- cytotoxic T-lymphocyte-associated protein 8
- cytotoxic T-lymphocyte-associated serine esterase 8
- IL-17
- IL-17A
- IL17
- ILA17
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin-17
- interleukin-17A
- NCBI_Gene: 3605
- UniProtKB: Q16552
Human IL17A Predicted Functions
Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of osteoclast differentiation. Acts upstream of or within positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Biomarker of several diseases, including acne; autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and rhinitis (multiple).
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Mouse Il17a Target Information
- Target Symbol: Il17a, interleukin 17A
- Alias:
- Ctla-8
- Ctla8
- cytotoxic T lymphocyte-associated protein 8
- IL-17A
- Il17
- interleukin 17
- NCBI_Gene: 16171
Mouse Il17a Predicted Functions
Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including defense response to other organism; intestinal epithelial structure maintenance; and positive regulation of gene expression. Acts upstream of or within cellular response to interleukin-1; positive regulation of cytokine production involved in inflammatory response; and positive regulation of transcription by RNA polymerase II. Located in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); eye disease (multiple); and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).
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Rat Il17a Target Information
- Target Symbol: Il17a, interleukin 17A
- Alias:
- CTLA-8
- cytotoxic T-lymphocyte-associated antigen 8
- hypothetical protein LOC301289
- IL-17
- IL-17A
- Il17
- interleukin 17
- Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin-17A
- LOC301289
- similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
- NCBI_Gene: 301289
Rat Il17a Predicted Functions
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).
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IL17A Target News
[catlist tags=”il17a” template=targetnews thumbnail=yes thumbnail_class=”related-post-media clr” thumbnail_size=833]
7.9
Amelioration of immunoglobulin A vasculitis by suppression of the pathological expansion of T follicular helper 17 cells
JOURNAL OF AUTOIMMUNITY
18.8
A citrullinated antigenic vaccine in treatment of autoimmune arthritis
Science Bulletin
4.2
Gut Microbiota Disorder Contributes to the Production of IL-17A That Exerts Chemotaxis via Binding to IL-17RA in Endometriosis
Journal of Inflammation Research
1.5
Effects of silencing NLRP3 gene on proliferation of psoriasis-like HaCaT cells and expressions of cytokines
CELLULAR AND MOLECULAR BIOLOGY
4.8
Small extracellular vesicles derived from human mesenchymal stem cells prevent Th17-dominant neutrophilic airway inflammation via immunoregulation on Th17 cells
INTERNATIONAL IMMUNOPHARMACOLOGY
7.1
DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis
Stem Cell Research & Therapy
5
Periodontitis aggravates COPD through the activation of γδ T cell and M2 macrophage
mSystems
5.6
SLAMF3 promotes Th17 differentiation and is reversed by iguratimod through JAK1/STAT3 pathway in primary Sjögren’s syndrome
INTERNATIONAL IMMUNOPHARMACOLOGY
4.8
Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses
Drug Design Development and Therapy
8.786
A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide.
Frontiers in Immunology
2.8
Characteristics of Serum Autoantibody Repertoire and Immune Subgroup Variation of Tuberculosis-Associated Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
11.3
Fe-curcumin nanozyme-mediated immunosuppression and anti-inflammation in experimental autoimmune uveitis
Biomaterials Research
3.6
Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
5.4
Modified Gegen Qinlian decoction ameliorated ulcerative colitis by attenuating inflammation and oxidative stress and enhancing intestinal barrier function in vivo and in vitro
JOURNAL OF ETHNOPHARMACOLOGY
3.7
A role of NR4A2 in Graves’ disease: regulation of Th17/Treg
ENDOCRINE
5.8
BMI-specific inflammatory response to phthalate exposure in early pregnancy: findings from the TMCHESC study
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
