Targeting STING Activation by Antigen-inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy

  • Impact factors: 19.924
  • Publication: ADVANCED FUNCTIONAL MATERIALS
  • Author:Wenxiu He, Xiao-Yong Zhang, Xiang Gong, Kuankuan Luo, Xuening Mao, Enhao Lu, Yiting Chen, Rui Wang, Zhiwen Zhang, Jing Zhao, Xianyi Sha
  • DOI citation-doi:10.1002/adfm.202212919
  • Date:2023-02-26

Immune checkpoint blockers therapy can improve the radiotherapy-induced immunosuppression by enhancing interferon secretion, but still suffer from low clinical response rate and potential adverse effects. Mn 2+ -mediated activation of interferon gene stimulator (STING) pathway provides an alternative for combination radioimmunotherapy of tumor. However, it still is a challenge for specific delivery of Mn 2+ to innate immune cells and targeting activation of STING pathway. Herein, a novel antigen-inspired MnO 2 nanovaccine was fabricated as Mn 2+ source and functionalized with mannose, enabling it to target innate immune cells to activate the STING pathway. Meanwhile, the release of Mn 2+ in the intracellular lysosomes can also be for magnetic resonance imaging to monitor the dynamic distribution of nanovaccines in vivo. The targeting activation of STING pathway can enhance radiotherapy-induced immune responses for inhibiting locally and distant tumors, and resisting tumor metastasis. The study proposes an optimized radiotherapy strategy through targeting STING activation of antigen-inspired nanovaccines. This article is protected by copyright. All rights reserved

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